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长脉冲高能量翠绿宝石激光治疗腿部毛细血管扩张症的评估

Evaluation of the long pulsed high fluence alexandrite laser therapy of leg telangiectasia.

作者信息

Brunnberg Stephanie, Lorenz Susanne, Landthaler Michael, Hohenleutner Ulrich

机构信息

Department of Dermatology, University Hospital of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

出版信息

Lasers Surg Med. 2002;31(5):359-62. doi: 10.1002/lsm.10117.

Abstract

BACKGROUND AND OBJECTIVES

The treatment of larger leg veins with laser or intense pulsed light often shows varying degrees of success and inconsistent clinical response rates. Aim of this study was to evaluate the effectiveness and safety of the 755 nm long pulsed high fluence alexandrite laser in the treatment of larger leg veins.

STUDY DESIGN/MATERIALS AND METHODS: Twenty female volunteers aged 25-51 years (mean 39) with 0.3-1.3 mm leg telangiectasias received laser treatment, 10 of them with an additional pass done right after the first pass. Their skin type ranged from 1 to 3 (five type 1, seven type 2, eight type 3). After test spots with increasing fluences (40-90 J/cm(2)) to determine the individual safe fluence, the maximum fluence of 90 J/cm(2) could be used in all 20 subjects. The spot size was 3 x 10 mm, a spray cooling system was used with 80 milliseconds spray and delay time, respectively. The number of pulses administered ranged from 30 to 467 per subject (mean 139). The treated area was controlled 1 day, 1 month, and 3 months post-treatment and the side effects were quantified. At each visit, the treatment area was photographed. The percent clearance in the treated areas was scored by two observers. Subject satisfaction was evaluated at the 3 months post-treatment visit.

RESULTS

After 3 months, in all 20 test subjects some clearance was visible. It ranged from low-grade to complete clearance. Most subjects (15 of 20) had a clearance between 26 and 75%. Hyperpigmentation was observed in 15 subjects. Hypopigmentation was seen in two subjects. No edema, no purpura, no erythema, no scarring, no blistering, and no crusts were observed. Mean subject satisfaction score was assessed and all volunteers reported to be "satisfied."

CONCLUSIONS

The long pulsed high fluence alexandrite laser is effective and safe in the treatment of leg veins 0.3-1.3 mm in diameter.

摘要

背景与目的

用激光或强脉冲光治疗较粗的腿部静脉,疗效往往存在不同程度的差异,临床有效率也不一致。本研究旨在评估755nm长脉冲高能量翠绿宝石激光治疗较粗腿部静脉的有效性和安全性。

研究设计/材料与方法:20名年龄在25至51岁(平均39岁)、腿部毛细血管扩张直径为0.3至1.3mm的女性志愿者接受了激光治疗,其中10人在首次治疗后紧接着进行了第二次治疗。她们的皮肤类型从1型到3型不等(5人1型,7人2型,8人3型)。在通过增加能量密度(40 - 90J/cm²)进行测试光斑以确定个体安全能量密度后,所有20名受试者均可使用90J/cm²的最大能量密度。光斑尺寸为3×10mm,使用喷雾冷却系统,喷雾时间和延迟时间分别为80毫秒。每位受试者接受的脉冲数在30至467个之间(平均139个)。在治疗后1天、1个月和3个月对治疗区域进行检查,并对副作用进行量化。每次随访时,对治疗区域进行拍照。由两名观察者对治疗区域的清除率进行评分。在治疗后3个月的随访中评估受试者的满意度。

结果

3个月后,所有20名受试对象的治疗区域均可见一定程度的清除。清除程度从轻度到完全清除不等。大多数受试者(20人中的15人)的清除率在26%至75%之间。15名受试者出现色素沉着。2名受试者出现色素减退。未观察到水肿、紫癜、红斑、瘢痕、水疱和结痂。评估了受试者的平均满意度评分,所有志愿者均表示“满意”。

结论

长脉冲高能量翠绿宝石激光治疗直径为0.3至1.3mm的腿部静脉有效且安全。

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