Hammes Stefan, Raulin Christian
Laserklinik Karlsruhe, Karlsruhe, Germany.
Lasers Surg Med. 2005 Feb;36(2):136-40. doi: 10.1002/lsm.20089.
Cold air cooling is widely used in dermatological laser therapy. We investigated the influence of cold air cooling at different skin temperatures on therapeutic outcome and side effects of pulsed dye laser treatment of facial telangiectasia.
STUDY DESIGN/MATERIALS AND METHODS: From September 2002 to February 2003, 17 patients with previously untreated facial telangiectasia underwent a single treatment session with flash-lamp pulsed dye laser (3.5 J/cm(2), 585 nm, 0.45 milliseconds pulse length, 10 mm beam diameter, Cynosure V). The treatment area was divided into three sub-areas: no cooling, cold air cooling to 20 degrees C and to 17 degrees C skin temperature. The skin temperature was monitored by a prototype infrared sensor system which controlled the temperature of the cold air stream (Cryo5). In a prospective study, we collected data on purpura, pain, clearance, and patient satisfaction on numerical analog scales (NAS) from 0 (meaning "no") to 3 (meaning "high").
Without cooling, purpura (2.53), pain (2.41), and clearance (2.35) were rated medium to high. Cooling to 20 degrees C reduced purpura (1.12) and pain (1.06), whereas the clearance (2.12) was only slightly affected. Cooling to 17 degrees C reduced purpura (0.88) and pain (0.76) even more, the clearance (2.06) was lowered marginally. Most patients preferred cooling to 20 degrees C skin temperature.
In dermatological laser therapy of facial telangiectasia, the use of cold air cooling can significantly reduce side effects and increase patient satisfaction while only slightly affecting clearance. Cooling to 20 degrees C skin temperature proved to be a well-balanced middle course. For the practical use of cold air cooling, we thus recommend cooling to a level which the patient can tolerate without problems and to try to increase the energy densities.
冷空气冷却在皮肤科激光治疗中被广泛应用。我们研究了不同皮肤温度下的冷空气冷却对面部毛细血管扩张症脉冲染料激光治疗的疗效及副作用的影响。
研究设计/材料与方法:2002年9月至2003年2月,17例未经治疗的面部毛细血管扩张症患者接受了单次闪光灯脉冲染料激光治疗(3.5 J/cm²,585 nm,0.45毫秒脉冲长度,10 mm光斑直径,Cynosure V)。治疗区域分为三个子区域:不冷却、冷空气冷却至皮肤温度20℃和17℃。皮肤温度由一个可控制冷气流温度的原型红外传感器系统(Cryo5)进行监测。在一项前瞻性研究中,我们通过数字模拟量表(NAS)从0(表示“无”)到3(表示“高”)收集了关于紫癜、疼痛、清除率和患者满意度的数据。
不冷却时,紫癜(2.53)、疼痛(2.41)和清除率(2.35)的评分中等至高。冷却至20℃可减轻紫癜(1.12)和疼痛(1.06),而清除率(2.12)仅受到轻微影响。冷却至17℃可进一步减轻紫癜(0.88)和疼痛(0.76),清除率(2.06)略有降低。大多数患者更喜欢将皮肤温度冷却至20℃。
在面部毛细血管扩张症的皮肤科激光治疗中,使用冷空气冷却可显著减少副作用并提高患者满意度,同时仅轻微影响清除率。将皮肤温度冷却至20℃被证明是一个平衡的中间方案。因此,对于冷空气冷却的实际应用,我们建议冷却至患者能够无问题耐受的水平,并尝试提高能量密度。