Synthesis of alpha-amino acid derivatives and amines via activation of simple alkyl halides by zinc in water.
作者信息
Huang Taisheng, Keh Charlene C K, Li Chao-Jun
机构信息
Department of Chemistry, Tulane University, New Orleans, LA, USA.
出版信息
Chem Commun (Camb). 2002 Oct 21(20):2440-1. doi: 10.1039/b204585k.
DOI:10.1039/b204585k
PMID:12430480
Abstract
A method for the synthesis of alpha-amino acid derivatives and amines is developed via a zinc-mediated conjugate addition reaction of alkyl halides to alpha-phthalimidoacrylate derivatives and nucleophilic addition to imines in the presence of NH4Cl in water. No reaction was observed in the absence of water.
摘要
Zotero 插件