通过组合生物合成对聚酮合酶后修饰步骤进行改造。
Modification of post-PKS tailoring steps through combinatorial biosynthesis.
作者信息
Rix Uwe, Fischer Carsten, Remsing Lily L, Rohr Jürgen
机构信息
Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536-0082, USA.
出版信息
Nat Prod Rep. 2002 Oct;19(5):542-80. doi: 10.1039/b103920m.
DOI:10.1039/b103920m
PMID:12430723
Abstract
This review covers the highlights of combinatorial biosynthesis applied on post-polyketide synthase modifying enzymes, such as oxygenases. ketoreductases, glycosyl- and methyltransferases, acyltransferases, halogenases, cyclases and aminotransferases Since this is the first review on this topic, it covers literature from 1985 to 2002, and 248 references are given.
摘要
本综述涵盖了组合生物合成应用于聚酮合酶后修饰酶（如加氧酶、酮还原酶、糖基转移酶、甲基转移酶、酰基转移酶、卤化酶、环化酶和转氨酶）的研究亮点。由于这是关于该主题的首次综述，其涵盖了1985年至2002年的文献，并列出了248篇参考文献。
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