Hagforsen Eva, Awder Mustafa, Lefvert Ann-Kari, Nordlind Klas, Michaëlsson Gerd
Department of Medical Sciences, University Hospital, Uppsala, Sweden.
Acta Derm Venereol. 2002;82(5):341-6. doi: 10.1080/000155502320624069.
Ninety-five percent of patients with palmoplantar pustulosis are smokers at onset of the disease. The aim of this study was to determine whether these patients have serum antibodies to nicotinic acetylcholine receptors (nAChR ab) and if their sera induce a specific immunofluorescence in normal palmar skin. Sera from 45 patients with palmoplantar pustulosis and 23 patients with chronic hand eczema were analysed for muscle nAChR ab, and immunofluorescence was performed on healthy palmar skin. Forty-two percent of the patients with palmoplantar pustulosis but none of the eczema patients had raised levels of nAChR ab. Immunofluorescence showed staining on endothelial cells in the papillary dermis in 47% of all sera from patients with palmoplantar pustulosis and in those with nAChR ab in 68%. On palmar skin from smokers there was also a staining of the sweat duct. Sera from patients with chronic hand eczema were negative. Our findings indicate that palmoplantar pustulosis is an autoimmune disease, possibly induced by smoking.
95%的掌跖脓疱病患者在疾病发作时吸烟。本研究的目的是确定这些患者是否具有抗烟碱型乙酰胆碱受体血清抗体（nAChR抗体），以及他们的血清是否会在正常手掌皮肤中诱导特异性免疫荧光。分析了45例掌跖脓疱病患者和23例慢性手部湿疹患者的血清中的肌肉nAChR抗体，并在健康的手掌皮肤上进行了免疫荧光检测。42%的掌跖脓疱病患者nAChR抗体水平升高，但湿疹患者均未出现这种情况。免疫荧光显示，掌跖脓疱病患者所有血清中有47%在乳头真皮的内皮细胞上有染色，nAChR抗体阳性的患者中有68%出现这种情况。吸烟者的手掌皮肤上汗腺导管也有染色。慢性手部湿疹患者的血清呈阴性。我们的研究结果表明，掌跖脓疱病是一种自身免疫性疾病，可能由吸烟诱发。
