Department of Medical Sciences, University of Uppsala, Uppsala, Sweden.
Arch Dermatol Res. 2010 Nov;302(9):685-93. doi: 10.1007/s00403-010-1070-3. Epub 2010 Jul 17.
Earlier findings indicate the acrosyringium as the target for the inflammation in the chronic and intensely inflammatory skin disease palmoplantar pustulosis (PPP). The sweat gland apparatus seems to be an immune-competent structure that probably contributes to the defence of the skin. Furthermore, the sweat gland and duct may be a hitherto unrecognized neuroendocrine organ because it expresses cholineacetyl-transferase and acetylcholinesterase, nicotinic receptors, beta-adrenergic and angiotensin receptors. The aim of this study was to obtain further information about neuroendocrine properties of the sweat gland apparatus by examining the expression of common neuroendocrine markers synaptophysin and chromogranins A and B in healthy palmar skin and in PPP skin. Synaptophysin and chromogranins were expressed in the sweat glands and ducts with some variation in the pattern and intensity of the expression. In PPP skin the expression differed, being higher and lower, depending on the part of the sweat duct. Chromogranins were further expressed in the epidermis, endothelium and inflammatory cells, but its intensity was weaker in epidermis than in the sweat gland apparatus. In most cases, chromogranins in epidermis in involved PPP were weakly expressed compared to healthy controls. The presence of synaptophysin and chromogranins in palmoplantar skin may have marked neuroendocrine effects, and the palmoplantar skin is likely to have important neuroimmuno-endocrine properties. Moreover, the altered chromogranin expression in PPP skin might influence both the neuroendocrine and neuroimmunologic properties of palmoplantar skin in these patients. These results indicate important neuroendocrine properties of the palmoplantar skin.
早期研究结果表明，在慢性和强烈炎症性皮肤病掌跖脓疱病（PPP）中，顶泌汗腺是炎症的靶标。汗腺装置似乎是一种具有免疫能力的结构，可能有助于皮肤防御。此外，汗腺和导管可能是一个迄今为止尚未被认识的神经内分泌器官，因为它表达胆碱乙酰转移酶和乙酰胆碱酯酶、烟碱受体、β-肾上腺素能受体和血管紧张素受体。本研究的目的是通过检查在健康掌部皮肤和 PPP 皮肤中常见神经内分泌标志物突触素和嗜铬粒蛋白 A 和 B 的表达，进一步了解汗腺装置的神经内分泌特性。突触素和嗜铬粒蛋白在汗腺和导管中表达，其表达模式和强度存在一些差异。在 PPP 皮肤中，其表达不同，取决于汗腺导管的部位，表达水平更高或更低。嗜铬粒蛋白进一步在表皮、内皮和炎症细胞中表达，但在表皮中的表达强度弱于在汗腺装置中的表达强度。在大多数情况下，PPP 受累表皮中的嗜铬粒蛋白表达弱于健康对照组。掌跖皮肤中存在突触素和嗜铬粒蛋白可能具有显著的神经内分泌作用，掌跖皮肤可能具有重要的神经免疫内分泌特性。此外，PPP 皮肤中嗜铬粒蛋白表达的改变可能会影响这些患者掌跖皮肤的神经内分泌和神经免疫特性。这些结果表明掌跖皮肤具有重要的神经内分泌特性。
