Valcavi U, Caponi R, Monterosso V, Balzano P, Palmira M, Favalli L, Chiari M C, Rozza A
Arzneimittelforschung. 1975 Nov;25(11):1695-7.
Ampicillin-guaiacolsulfonate, a new derivative of ampicillin, preserves the antibacterial properties of ampicillin, is suitable for infection owing to its good water solubility and it has far higher stability in dry state than has sodium ampicillin. Ampicillin-guaiacolsulfonate is better orally absorbed in rabbit than is ampicillin. In vitro experiments carried out with the model system by Rosano and Schulman, and measurements of the intestinal absorption in the everted sac jejunal preparation, carried out with 14C-labelled compounds, demonstrate that the new ampicillin derivative is better absorbed by the intestine because of an increase in the intestinal permeability of the molecule itself.
氨苄西林愈创木酚磺酸盐是氨苄西林的一种新衍生物，它保留了氨苄西林的抗菌特性，因其良好的水溶性适用于感染，并且在干燥状态下比氨苄西林钠具有更高的稳定性。氨苄西林愈创木酚磺酸盐在兔体内的口服吸收比氨苄西林更好。用Rosano和Schulman的模型系统进行的体外实验，以及用14C标记化合物在翻转囊空肠制剂中进行的肠道吸收测量表明，这种新的氨苄西林衍生物由于分子本身肠道通透性的增加而被肠道更好地吸收。
