Jauch R, Hankwitz R, Beschke K, Pelzer H
Arzneimittelforschung. 1975 Nov;25(11):1796-1800.
After both oral and rectal administration in humans (4,4'-diacetoxy-diphenyl)-(pyridyl-2)-methane (bisacodyl, Dulcolax) and 4,4'-(2-pyridyl-methylene)-diphenol-disulfuric acid semiester disodium (sodium picosulfate, Laxoberal) are hydrolyzed to bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM). In both cases BHPM is responsible for the laxative action. Experiments in rats and guinea pigs have shown that the hydrolysis of picosulfate, in contrast to that of bisacodyl, is attributable to the microorganisms of the intestinal flora.
在人体中经口服和直肠给药后，（4,4'-二乙酰氧基二苯基）-（2-吡啶基）-甲烷（比沙可啶，杜秘克）和4,4'-（2-吡啶基亚甲基）-二苯酚-二硫酸半酯二钠盐（匹可硫酸钠，乐可舒）均会水解为双-（对羟基苯基）-2-吡啶基甲烷（BHPM）。在这两种情况下，BHPM都是产生通便作用的原因。在大鼠和豚鼠身上进行的实验表明，与比沙可啶不同，匹可硫酸盐的水解归因于肠道菌群中的微生物。
