德国健康人群及有经肠外传播疾病风险个体中SENV-H病毒血症的患病率。

Prevalence of SENV-H viraemia among healthy subjects and individuals at risk for parenterally transmitted diseases in Germany.

作者信息

Schröter M, Laufs R, Zöllner B, Knödler B, Schäfer P, Sterneck M, Fischer L, Feucht H-H

机构信息

Institut für Medizinische Mikrobiologie und Immunologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

出版信息

J Viral Hepat. 2002 Nov;9(6):455-9. doi: 10.1046/j.1365-2893.2002.00390.x.

DOI:10.1046/j.1365-2893.2002.00390.x

PMID:12431209

Abstract

The prevalence of a newly described DNA virus (SENV-H) was examined in a population of 599 individuals by polymerase chain reaction (PCR). All individuals were assigned to a nonrisk or a risk group depending on the presence of historical or serological factors indicating an increased risk for parenterally transmitted diseases. In a group of 226 healthy blood donors, 38 (16.8%) were found to be SENV-H viraemic. The highest prevalence of SENV-H viraemia was observed among patients infected by HIV (28 of 63; 44.4%). Contrarily, of 78 individuals on maintenance haemodialysis, only 10 (12.8%) were found positive in the SENV-H PCR. Our results demonstrate that SENV-H viraemia is widespread in the general population. Therefore, it seems to be questionable if parenteral transmission is the main route for spreading SENV-H. The hepatitis-inducing capacity of SENV-H is unclear. However, taking our clinical and epidemiological data into account it seems unlikely that this virus is responsible for hepatitis.

摘要

通过聚合酶链反应（PCR）检测了599名个体中一种新发现的DNA病毒（SENV-H）的流行情况。根据表明经肠道外传播疾病风险增加的既往史或血清学因素，将所有个体分为无风险组或风险组。在226名健康献血者中，发现38人（16.8%）存在SENV-H病毒血症。在感染HIV的患者中观察到SENV-H病毒血症的患病率最高（63例中有28例；44.4%）。相反，在78名维持性血液透析患者中，只有10人（12.8%）的SENV-H PCR检测呈阳性。我们的结果表明，SENV-H病毒血症在普通人群中广泛存在。因此，肠道外传播是否为SENV-H传播的主要途径似乎值得怀疑。SENV-H诱导肝炎的能力尚不清楚。然而，综合我们的临床和流行病学数据来看，这种病毒似乎不太可能导致肝炎。