麦角隐亭与仓鼠的妊娠维持

Ergocryptine and pregnancy maintenance in hamsters.

作者信息

Ford J J, Yoshinaga K

出版信息

Proc Soc Exp Biol Med. 1975 Nov;150(2):425-7. doi: 10.3181/00379727-150-39049.

Abstract

Ergocryptine (ECR) terminated pregnancy in hamsters when administered on Day 5; when ECR was given on Day 6 the response was diminished, and pregnancy continued after ECR treatment on Day 7. The abortifacient action of ECR in Day 5 pregnant hamsters was overcome by exogenous prolactin but not FSH and LH. When sera collected from hamsters on different days of gestation were examined for their ability to neutralize the effect of ECR in Day 5 pregnant hamsters, a peak of luteotrophic activity was observed in sera collected on Days 10 and 11. The results of these studies suggest that in hamsters the role of hypophyseal prolactin in luteal support is diminished by Day 7 of pregnancy, and the appearance of luteotrophic activity in sera collected on Days 10 and 11 may be indicative of a placental luteotrophin.

摘要

麦角隐亭（ECR）在第5天给药时可使仓鼠终止妊娠；在第6天给予ECR时，反应减弱，而在第7天给予ECR治疗后妊娠继续。外源性催乳素可克服ECR对第5天妊娠仓鼠的堕胎作用，但促卵泡生成素和促黄体生成素则不能。当检测从妊娠不同天数的仓鼠收集的血清中和第5天妊娠仓鼠中ECR作用的能力时，在第10天和第11天收集的血清中观察到黄体营养活性高峰。这些研究结果表明，在仓鼠中，垂体催乳素在黄体支持中的作用在妊娠第7天时减弱，而在第10天和第11天收集的血清中黄体营养活性的出现可能表明存在胎盘促黄体激素。