心脏病中的抗心肌抗体。II. 风湿热和风湿性心脏病的免疫荧光模式。
Antimyocardial antibodies in heart diseases. II. Immunofluorescent patterns in rheumatic fever and rheumatic heart disease.
作者信息
Boeriu I N, Dejica D, Boloşiu H D, Duma V
出版信息
Med Interne. 1975;13(2):147-52.
Antibodies against rat myocardium were studied by means of histoimmunfluorescence (indirect technique) in 32 rheumatic fever patients. Antibodies were found in 54% of the cases without carditis or active rheumatic valvulitis and in 83% of those with carditis. The fluorescent patterns observed were : sarcolemmal, sarcoplasmic (intermyofibrillar) and smooth muscle of vessels. The sarcolemmal pattern was more frequently observed in rheumatic carditis while the intermyofibrillar one was more common in rheumatic fever without evidence of carditis as well as rheumatic valvulitis. The serum factors involved in the sarcolemmal fluorescence were inhibitied by the insoluble saline myocardium extract.
采用组织免疫荧光法（间接技术）对32例风湿热患者进行了抗大鼠心肌抗体研究。在无心脏炎或活动性风湿性瓣膜炎的患者中，54%检测到抗体；在有心脏炎的患者中，83%检测到抗体。观察到的荧光模式有：肌膜、肌浆（肌原纤维间）和血管平滑肌。肌膜模式在风湿性心脏炎中更常见，而肌原纤维间模式在无心脏炎证据的风湿热以及风湿性瓣膜炎中更常见。肌膜荧光所涉及的血清因子可被不溶性盐水心肌提取物抑制。
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