Shastry P, Naik S, Joshi M, Kinare S
Department of Pathology, King Edward Memorial Hospital, Bombay, India.
J Clin Lab Immunol. 1988 Oct;27(2):87-90.
Heart Reactive Antibodies (HRA) of IgG and IgM classes were investigated in 79 patients in four clinically classified groups. Group I comprised of 16 children with Acute Rheumatic Fever (ARF) and Group II consisted of 15 cases with active Rheumatic Heart Disease (RHD). Twenty seven cases of ARF and RHD in remission and 21 adults with quiescent RHD were included in Groups III and IV respectively. Control groups comprised of 14 normal, healthy, donors and eight Post Streptococcal Acute Glomerular Nephritis (PSAGN) cases. Low levels of HRA of IgG and IgM classes were detected in control groups. The overall incidence of HRA of IgG and IgM classes was 82.28 and 39.24% respectively in the patient group. An increased frequency of HRA-IgM antibodies was observed in Groups I, III and IV (p less than 0.01, 0.001 and 0.025 respectively). All the four groups demonstrated a highly significant increase in incidence of HRA--IgG class (p less than 0.0005). Persistence of high titres of HRA-IgG class in ARF and RHD is reported in the paper.
在四个临床分类组的79名患者中研究了IgG和IgM类心脏反应性抗体（HRA）。第一组包括16名急性风湿热（ARF）儿童，第二组由15例活动性风湿性心脏病（RHD）患者组成。第三组和第四组分别纳入了27例缓解期的ARF和RHD患者以及21例静止期RHD成人患者。对照组包括14名正常健康供体和8例链球菌感染后急性肾小球肾炎（PSAGN）病例。在对照组中检测到低水平的IgG和IgM类HRA。患者组中IgG和IgM类HRA的总体发生率分别为82.28%和39.24%。在第一组、第三组和第四组中观察到HRA-IgM抗体频率增加（分别为p<0.01、0.001和0.025）。所有四组的HRA-IgG类发生率均显著增加（p<0.0005）。该论文报道了ARF和RHD中HRA-IgG类高滴度的持续存在。
