Buchman Timothy G
Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110-1093, USA.
Nature. 2002 Nov 14;420(6912):246-51. doi: 10.1038/nature01260.
Good health, which reflects the harmonious integration of molecules, cells, tissues and organs, is dynamically stable: when displaced by disease, compensation and correction are common, even without medical care. Physiology and computational biology now suggest that healthy dynamic stability arises through the combination of specific feedback mechanisms and spontaneous properties of interconnected networks. Today's physicians are already testing to 'see if the network is right'; tomorrow's physicians may well use therapies to 'make the network right'.
良好的健康状况反映了分子、细胞、组织和器官的和谐整合,它是动态稳定的:当因疾病而失衡时,即使没有医疗干预,代偿和纠正也很常见。生理学和计算生物学目前表明,健康的动态稳定性源于特定反馈机制与相互连接网络的自发特性的结合。如今的医生已经在测试“看网络是否正常”;未来的医生很可能会使用疗法来“让网络恢复正常”。