Karring T, Lang N P, Löe H
J Periodontal Res. 1975 Feb;10(1):1-11. doi: 10.1111/j.1600-0765.1975.tb00001.x.
Free grafts of connective tissue, without epithelium, were transplanted from either the keratinized gingiva or the non-keratinized alveolar mucosa (controls) into areas of the alveolar mucosa in seven monkeys. The grafts were placed in pouches created in the connective tissue as close as possible to the overlying epithelium. After 3-4 weeks, the transplants were exposed by removal of the overlying tissue in order to allow epithelialization from the surrounding non-keratinized alveolar mucosa. The transplants were examined clinically and histologically at time peiods between 1 and 12 months. The gingival connective tissue grafts became covered with keratinized epithelium displaying the same characteristics as those of normal gingival epithelium. The alveolar mucosa transplants were covered with non-keratinized epithelium. This indicated that gingival connective tissue is capable of inducing the formation of a keratinized gingival epithelium.
将无上皮的结缔组织游离移植片，取自角化牙龈或非角化牙槽黏膜（对照组），移植到7只猴子的牙槽黏膜区域。将移植片置于结缔组织中尽可能靠近覆盖上皮的袋内。3 - 4周后，通过去除覆盖组织使移植片暴露，以便周围非角化牙槽黏膜上皮化。在1至12个月的时间段内对移植片进行临床和组织学检查。牙龈结缔组织移植片被角化上皮覆盖，显示出与正常牙龈上皮相同的特征。牙槽黏膜移植片被非角化上皮覆盖。这表明牙龈结缔组织能够诱导角化牙龈上皮的形成。
