Chavanu Kathleen J, O'Donnell Dannielle C
Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois 60515, USA.
Pharmacotherapy. 2002 Nov;22(11):1442-57. doi: 10.1592/phco.22.16.1442.33701.
Menstrual migraines are a treatment challenge for both the migraineur and the health care professional. Although some women with menstrual migraines may respond to acute and preventive therapies for nonmenstrual migraines, others continue to suffer from refractory menstrual migraines. These women may respond to hormonal interventions, which may reduce the frequency of menstrual migraines, thereby lessening the need for abortive migraine therapies, decreasing migraine-related disability, and improving quality of life. Menstrual migraines have a distinct pathophysiology that differs from menstrual-related migraines. Published studies have shed light on the effectiveness of a variety of hormonal interventions, including oral contraceptives, which may be administered with an extended-dosing strategy; estrogen replacement therapy; selective estrogen receptor modifiers; danazol; and leuprolide.
月经性偏头痛对偏头痛患者和医疗保健专业人员来说都是一个治疗难题。虽然一些患有月经性偏头痛的女性可能对非月经性偏头痛的急性和预防性治疗有反应，但另一些女性仍患有难治性月经性偏头痛。这些女性可能对激素干预有反应，这可能会减少月经性偏头痛的发作频率，从而减少使用偏头痛缓解疗法的必要性，降低与偏头痛相关的残疾程度，并提高生活质量。月经性偏头痛有与月经相关偏头痛不同的独特病理生理学。已发表的研究揭示了多种激素干预措施的有效性，包括可采用延长给药策略的口服避孕药、雌激素替代疗法、选择性雌激素受体调节剂、达那唑和亮丙瑞林。
