Yamamoto Toshiyuki, Yokozeki Hiroo, Nishioka Kiyoshi
Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan.
J Dermatol. 2002 Oct;29(10):638-43. doi: 10.1111/j.1346-8138.2002.tb00194.x.
We herein report six cases of localized involutional lipoatrophy, who presented with a depressive plaque on the lateralis of the upper arm. All patients were female, and three had previous injections for allergic rhinitis at the affected sites before the development of lipoatrophy. One patient received intramuscular injection at the affected site when she had a cold. Histological examination showed fat lobules composed of small lipocytes in the hyaline connective tissue. Immunohistochemical examination revealed a number of CD68-positive macrophages in the fat lobules. We consider that localized involutional lipoatrophy is more common than has been reported, and is occasionally induced by local injections.
我们在此报告6例局限性萎缩性脂肪营养不良病例，这些病例均表现为上臂外侧出现凹陷性斑块。所有患者均为女性，其中3例在脂肪萎缩发生前曾在受影响部位注射过治疗过敏性鼻炎的药物。1例患者感冒时在受影响部位接受了肌肉注射。组织学检查显示，透明结缔组织中有由小脂肪细胞组成的脂肪小叶。免疫组织化学检查显示脂肪小叶中有大量CD68阳性巨噬细胞。我们认为局限性萎缩性脂肪营养不良比报道的更为常见，且偶尔由局部注射引起。
