Abbas Ossama, Salman Salah, Kibbi Abdul Ghani, Chedraoui Adele, Ghosn Samer
Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
J Am Acad Dermatol. 2008 Mar;58(3):490-3. doi: 10.1016/j.jaad.2007.06.030.
Localized involutional lipoatrophy (LIL) was first described in 1986 as a distinctive idiopathic form of localized lipoatrophy characterized by loss of adipose tissue without antecedent inflammation. Clinically, LIL usually presents as a solitary, asymptomatic, well-demarcated, atrophic depression and often involves areas of antecedent intramuscular or intra-articular injections. Histologically, changes in the subcutaneous fat in LIL resemble fetal adipose tissue. Only rarely has there been any description of epidermal or dermal changes occurring with LIL. We describe two cases of LIL with overlying hypopigmentation and atrophy, and with morphea-like changes on histology. Recognition of these changes may have clinical and diagnostic implications.
局限性退行性脂肪萎缩（LIL）于1986年首次被描述为一种独特的特发性局限性脂肪萎缩形式，其特征是脂肪组织缺失且无先前炎症。临床上，LIL通常表现为孤立的、无症状的、边界清晰的萎缩性凹陷，常累及先前肌肉内或关节内注射的部位。组织学上，LIL中皮下脂肪的变化类似于胎儿脂肪组织。关于LIL伴发表皮或真皮变化的描述极为罕见。我们报告两例LIL病例，其上方有色素减退和萎缩，组织学上有硬斑病样改变。认识到这些变化可能具有临床和诊断意义。
