Herman Steve, Blumenthal James A, Babyak Michael, Khatri Parinda, Craighead W Edward, Krishnan K Ranga, Doraiswamy P Murali
Health Psychol. 2002 Nov;21(6):553-63.
Psychosocial factors predicting treatment dropout or failure to benefit from treatment were identified in a randomized trial of exercise therapy and pharmacotherapy for major depression. One hundred fifty-six men and women over age 50 diagnosed with major depressive disorder were assigned to a 16-week program of aerobic exercise, medication (sertraline), or a combination of exercise and medication. Thirty-two patients (21%) failed to complete the program and were considered treatment "dropouts." At the end of 16 weeks, 83 patients (53%) were in remission; the remaining patients not in remission were considered treatment "failures." Baseline levels of self-reported anxiety and lift satisfaction were the best predictors of both patient dropout and treatment success or failure across all treatment conditions.
在一项针对重度抑郁症的运动疗法和药物疗法的随机试验中，确定了预测治疗中断或无法从治疗中获益的心理社会因素。156名年龄在50岁以上、被诊断患有重度抑郁症的男性和女性被分配到一个为期16周的有氧运动、药物治疗（舍曲林）或运动与药物联合治疗项目中。32名患者（21%）未能完成该项目，被视为治疗“退出者”。在16周结束时，83名患者（53%）病情缓解；其余未缓解的患者被视为治疗“失败者”。自我报告的焦虑和生活满意度的基线水平是所有治疗条件下患者退出以及治疗成功或失败的最佳预测指标。
