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关于“骨质疏松症”、骨骼健康、强度、脆性及其决定因素的新观点。

Emerging views about "osteoporosis", bone health, strength, fragility, and their determinants.

作者信息

Frost Harold M

机构信息

Department of Orthopaedic Surgery, Southern Colorado Clinic, PO Box 9000, Pueblo 81008-9000, USA.

出版信息

J Bone Miner Metab. 2002;20(6):319-25. doi: 10.1007/s007740200046.

Abstract

Recent articles by Drs. Lanyon, Raisz, Seeman, and Skerry summarized some emerging views about the causes and nature of some effects of mechanical loading on bones and "osteoporosis", the causes of fractures in that condition, and the causes of increased bone fragility and age-related bone loss. This article would supplement theirs with further evidence and ideas. This includes a definition of bone health that suggests currently popular classifications of "osteoporosis" and "osteopenia" could fail to distinguish healthy differences from normal averages from true bone diseases. This definition also suggests a classification of osteoporotic fractures that could question some current methods and uses of noninvasive absorptiometry. This article emphasizes concepts and generalities, and leaves resolution of any devils in the details to other places, times, and people.

摘要

兰尼恩博士、赖兹博士、西曼博士和斯凯里博士近期发表的文章总结了一些关于机械负荷对骨骼的某些影响及其“骨质疏松症”的成因和本质、该病症中骨折的原因以及骨脆性增加和与年龄相关的骨质流失的原因等方面的新观点。本文将用更多证据和观点对他们的文章进行补充。这包括对骨骼健康的定义,该定义表明当前流行的“骨质疏松症”和“骨质减少”分类可能无法区分健康差异、正常平均值与真正的骨骼疾病。这个定义还提出了一种骨质疏松性骨折的分类方法,这可能会对当前一些非侵入性骨密度测定法的方法和用途提出质疑。本文强调概念和一般性内容,而将细节方面的任何难题留待其他时间、地点和人员去解决。

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