Wood Richard J, O'Neill Elizabeth C
Department of Exercise Science & Sport Studies, Springfield College, 263 Alden St. Athletic Training/Exercise Science Complex, Springfield, MA 01109, USA.
J Nutr Metab. 2012;2012:268197. doi: 10.1155/2012/268197. Epub 2012 Feb 6.
The prevalence of Type II Diabetes mellitus (T2DM) is increasing rapidly and will continue to be a major healthcare expenditure burden. As such, identification of effective lifestyle treatments is paramount. Skeletal muscle and bone display metabolic and functional disruption in T2DM. Skeletal muscle in T2DM is characterized by insulin resistance, impaired glycogen synthesis, impairments in mitochondria, and lipid accumulation. Bone quality in T2DM is decreased, potentially due to the effects of advanced glycation endproducts on collagen, impaired osteoblast activity, and lipid accumulation. Although exercise is widely recognized as an important component of treatment for T2DM, the focus has largely been on aerobic exercise. Emerging research suggests that resistance training (strength training) may impose potent and unique benefits in T2DM. The purpose of this review is to examine the role of resistance training in treating the dysfunction in skeletal muscle and the potential role for resistance training in treating the associated dysfunction in bone.
2型糖尿病（T2DM）的患病率正在迅速上升，并将继续成为主要的医疗支出负担。因此，确定有效的生活方式治疗方法至关重要。在T2DM中，骨骼肌和骨骼会出现代谢和功能紊乱。T2DM中的骨骼肌具有胰岛素抵抗、糖原合成受损、线粒体功能障碍和脂质蓄积等特征。T2DM中的骨质量下降，这可能是由于晚期糖基化终产物对胶原蛋白的影响、成骨细胞活性受损以及脂质蓄积所致。尽管运动被广泛认为是T2DM治疗的重要组成部分，但重点主要放在有氧运动上。新出现的研究表明，抗阻训练（力量训练）可能对T2DM具有强大且独特的益处。本综述的目的是探讨抗阻训练在治疗骨骼肌功能障碍中的作用以及抗阻训练在治疗相关骨骼功能障碍中的潜在作用。
