Berkes István, Harbula Ildikó, Kynsburg Akos, Falus András
Országos Sportegészségügyi Intézet, Budapest.
Orv Hetil. 2002 Sep 15;143(37):2131-3.
The application of gene therapy to sports medicine is in its infancy, but it holds much promise as a novel procedure to improve the clinical management of sports injuries. Gene therapy will be particularly useful in initiating and accelerating the repair of cartilage, meniscus, tendon, and ligament. Several growth factors and other cytokines have been identified as important mediators of a successful healing process. Such molecules have promise as novel agents for the treatment of sports injuries, but there is presently no clinically useful way to deliver them. Gene transfer may be used to serve this purpose. Gene therapy functions as a type of local biological drug delivery system. Recent studies have shown the feasibility of transferring marker genes to synovium, chondrocytes, meniscal fibrochondrocytes, tenocytes and ligamental fibroblasts, prompting optimism about the eventual success of this approach.
基因疗法在运动医学中的应用尚处于起步阶段，但作为一种改善运动损伤临床治疗的新方法，它具有很大的前景。基因疗法在启动和加速软骨、半月板、肌腱和韧带的修复方面将特别有用。几种生长因子和其他细胞因子已被确定为成功愈合过程的重要介质。这类分子有望成为治疗运动损伤的新型药物，但目前尚无临床上有用的给药方法。基因转移可用于实现这一目的。基因疗法起着一种局部生物药物递送系统的作用。最近的研究表明，将标记基因转移到滑膜、软骨细胞、半月板纤维软骨细胞、肌腱细胞和韧带成纤维细胞中是可行的，这让人们对这种方法最终取得成功充满乐观。
