Hildebrand K A, Frank C B, Hart D A
McCaig Centre for Joint Injury and Arthritis Research, University of Calgary, Calgary, AB, Canada.
Gene Ther. 2004 Feb;11(4):368-78. doi: 10.1038/sj.gt.3302198.
Ligament and tendon injuries are common clinical problems. Healing of these tissues occurs, but their properties do not return to normal. This predisposes to recurrent injuries, instability and arthritis, loss of motion and weakness. Gene therapy offers a novel approach to the repair of ligaments and tendons. Introduction of genes into ligaments and tendons using vectors has been successful. Marker genes and therapeutic genes have been introduced into both tissues with evidence of corresponding functional alterations. In addition, gene transfer has been used to manipulate the healing environment, opening the possibility of gene transfer to investigate ligament and tendon development and homeostasis, in addition to using this technology therapeutically. Several factors modulate the 'success' of gene transfer in these tissues.
韧带和肌腱损伤是常见的临床问题。这些组织能够愈合，但其特性无法恢复正常。这就容易引发反复损伤、不稳定和关节炎、活动丧失以及无力。基因治疗为韧带和肌腱的修复提供了一种新方法。使用载体将基因导入韧带和肌腱已取得成功。标记基因和治疗基因已被导入这两种组织，并出现了相应功能改变的证据。此外，基因转移已被用于调控愈合环境，这除了在治疗中使用该技术外，还为研究韧带和肌腱的发育及内稳态开启了基因转移的可能性。有几个因素会调节这些组织中基因转移的“成功率”。
