Román Rossana, Vallejos María Eliana, Muñoz Mónica, Schneider Ruth, Youlton Ronald, Henriquez Cecilia, Cassorla Fernando
Instituto de Investigaciones Materno-Infantil, Facultad de Medicina, Campus Centro, Universidad de Chile.
Rev Med Chil. 2002 Sep;130(9):977-84.
Short stature is the main feature of patients with Turner's syndrome. There is limited information regarding the spontaneous growth of these patients in Chile.
To develop a specific growth chart for Chilean patients with Turner's syndrome.
We retrospectively analyzed 668 height measurements from 85 Chilean girls, born after 1968, with 45XO karyotype (minimum 15%), and without an Y chromosome fragment. Patients with hormonal therapy, such as growth hormone or estrogen, except thyroid hormone replacement, were excluded.
The karyotypes were 60% 45XO, 25% 45XO, 46XX, and 15% other complex mosaics. The birth length was 46.8 +/- 2.1 cm. The final height of our patients was 138,20 +/- 7.0 cm.
The final height achieved by our patients, is similar to Argentinian and Japanese patients, but is below the mean stature reported for Scandinavian and Northamerican patients who achieve a mean adult height of approximately 147 and 142 cm respectively. The birth length is also lower than that reported in those studies.
身材矮小是特纳综合征患者的主要特征。在智利，关于这些患者自然生长情况的信息有限。
为智利特纳综合征患者制定特定的生长图表。
我们回顾性分析了1968年以后出生的85名智利女孩的668次身高测量数据，这些女孩核型为45XO（至少15%）且无Y染色体片段。排除接受过生长激素或雌激素等激素治疗的患者，但甲状腺激素替代治疗的患者除外。
核型为60% 45XO、25% 45XO/46XX以及15%其他复杂嵌合体。出生时身长为46.8±2.1厘米。我们患者的最终身高为138.20±7.0厘米。
我们患者所达到的最终身高与阿根廷和日本患者相似，但低于斯堪的纳维亚和北美患者报告的平均身高，后者的平均成人身高分别约为147厘米和142厘米。出生时身长也低于那些研究报告的数值。
