Bertapelli Fabio, Barros-Filho Antonio de Azevedo, Antonio Maria Ângela Reis de Góes Monteiro, Barbeta Camila Justino de Oliveira, de Lemos-Marini Sofia Helena Valente, Guerra-Junior Gil
Growth and Development Lab, Center for Investigation in Pediatrics (CIPED), School of Medicine, State University of Campinas (UNICAMP), 13083-887 Campinas, SP, Brazil.
Department of Pediatrics, School of Medicine, State University of Campinas (UNICAMP), 13083-887 Campinas, SP, Brazil.
Biomed Res Int. 2014;2014:687978. doi: 10.1155/2014/687978. Epub 2014 May 15.
The objective of this study was to review the growth curves for Turner syndrome, evaluate the methodological and statistical quality, and suggest potential growth curves for clinical practice guidelines. The search was carried out in the databases Medline and Embase. Of 1006 references identified, 15 were included. Studies constructed curves for weight, height, weight/height, body mass index, head circumference, height velocity, leg length, and sitting height. The sample ranged between 47 and 1,565 (total = 6,273) girls aged 0 to 24 y, born between 1950 and 2006. The number of measures ranged from 580 to 9,011 (total = 28,915). Most studies showed strengths such as sample size, exclusion of the use of growth hormone and androgen, and analysis of confounding variables. However, the growth curves were restricted to height, lack of information about selection bias, limited distributional properties, and smoothing aspects. In conclusion, we observe the need to construct an international growth reference for girls with Turner syndrome, in order to provide support for clinical practice guidelines.
本研究的目的是回顾特纳综合征的生长曲线，评估方法学和统计学质量，并为临床实践指南提出潜在的生长曲线。检索在Medline和Embase数据库中进行。在识别出的1006篇参考文献中，纳入了15篇。研究构建了体重、身高、体重/身高、体重指数、头围、身高增长速度、腿长和坐高的曲线。样本包括47至1565名（总计6273名）年龄在0至24岁之间的女孩，她们出生于1950年至2006年。测量次数从580次到9011次（总计28915次）。大多数研究显示出一些优势，如样本量、排除生长激素和雄激素的使用以及对混杂变量的分析。然而，生长曲线仅限于身高，缺乏关于选择偏倚的信息，分布特性有限，以及平滑方面的问题。总之，我们认为有必要为特纳综合征女孩构建一个国际生长参考标准，以便为临床实践指南提供支持。
