Ozen Naile, Uslu Ezel, Ozen Metehan, Aydin Seval, Altug Tuncay, Belce Ahmet, Kokoglu Emine
Biochemistry Laboratory, Malatya State Hospital, Turkey.
Tohoku J Exp Med. 2002 Aug;197(4):221-7. doi: 10.1620/tjem.197.221.
In this study, we determined curcumin's anticancer and chemopreventive effects in mice bearing Ehrlich ascites tumor by evaluation of cancer biomarkers, sialic acid level and sialidase activity. Both plasma sialic acid level and sialidase activity increased significantly in the mice group with Ehrlich ascites tumor. When the tumor groups fed with curcumin and fed with sesame oil were compared, sialic acid level and sialidase activity in ascites fluid significantly reduced in the group fed with curcumin in addition to the increases of plasma sialic acid level and sialidase activity. The tumor group fed with curcumin lived twice longer than the one fed with sesame oil. Curcumin as a phenolic compound decreased all these parameters in Ehrlich ascites tumors and lengthened survival by 88% in the mice with tumor. We concluded that curcumin has anticancer activity.
在本研究中，我们通过评估癌症生物标志物、唾液酸水平和唾液酸酶活性，确定了姜黄素对携带艾氏腹水瘤小鼠的抗癌和化学预防作用。艾氏腹水瘤小鼠组的血浆唾液酸水平和唾液酸酶活性均显著升高。当比较喂食姜黄素的肿瘤组和喂食芝麻油的肿瘤组时，除血浆唾液酸水平和唾液酸酶活性增加外，喂食姜黄素组的腹水液中唾液酸水平和唾液酸酶活性显著降低。喂食姜黄素的肿瘤组存活时间比喂食芝麻油的肿瘤组长两倍。姜黄素作为一种酚类化合物，降低了艾氏腹水瘤中的所有这些参数，并使荷瘤小鼠的生存期延长了88%。我们得出结论，姜黄素具有抗癌活性。
