Eaton Tracy J, Gasson Michael J
Institute of Food Research, Norwich Research Park, Colney, NR4 7UA, Norwich, UK.
FEMS Microbiol Lett. 2002 Nov 5;216(2):269-75. doi: 10.1111/j.1574-6968.2002.tb11446.x.
Enterococci are increasingly important causes of nosocomial disease. Also, they are associated with food and have a history of use as dairy starter and probiotic cultures. An enterococcal surface protein Esp(fs) is involved the virulence and biofilm-forming capacity of Enterococcus faecalis and recently we demonstrated the presence of a homologue Esp(fm) in E. faecium. Here we describe the complete structure of Esp(fm) and demonstrate that its distribution in E. faecium correlates with disease associated strains from a range of pathological sites.
肠球菌是医院感染日益重要的病因。此外，它们与食物有关，并且有作为乳制品发酵剂和益生菌培养物的使用历史。一种肠球菌表面蛋白Esp(fs)与粪肠球菌的毒力和生物膜形成能力有关，最近我们证明了屎肠球菌中存在一种同源物Esp(fm)。在这里，我们描述了Esp(fm)的完整结构，并证明了它在屎肠球菌中的分布与来自一系列病理部位的疾病相关菌株相关。
