Wygold Thorsten
University Children's Hospital, Medical University of Lübeck, Germany.
Horm Res. 2002;58 Suppl 3:20-3. doi: 10.1159/000066485.
Although growth hormone does not clearly improve final height in non-growth-hormone-deficient children with short stature, it leads to a temporary acceleration of growth velocity. It is an ongoing discussion whether this effect supports psychosocial adaptation to short stature and therefore could be an indication for growth hormone treatment in children with short stature without growth hormone deficiency. We have reviewed recent literature concerning psychosocial consequences of short stature. Together with own data we can demonstrate that short people regularly adapt well to their height and have a good self-esteem. On the other hand, we focus on the problem that most studies on this subject suffer from methodical problems. A growth-related questionnaire that evaluates subjective and objective perceptions of being short in patients and peers is not at hand. As a consequence, psychosocial problems due to short stature have not been exactly classified yet and therefore do not represent an indication for growth hormone therapy.
尽管生长激素并不能明显提高非生长激素缺乏型身材矮小儿童的最终身高,但它会使生长速度暂时加快。身材矮小是否有利于心理社会适应,进而是否可作为生长激素缺乏症以外的身材矮小儿童生长激素治疗的指征,仍是一个正在进行的讨论话题。我们回顾了近期有关身材矮小心理社会后果的文献。结合我们自己的数据可以证明,身材矮小的人通常能很好地适应自己的身高,且自尊心较强。另一方面,我们关注的问题是,大多数关于这个主题的研究都存在方法上的问题。目前还没有一个能评估患者及其同龄人对身材矮小的主观和客观认知的与生长相关的问卷。因此,身材矮小导致的心理社会问题尚未得到准确分类,所以并不构成生长激素治疗的指征。