Zlotkin David, Varma Surendra K
Department of Pediatrics, Texas Tech University Health Sciences Center, Lubbock, USA.
Indian J Pediatr. 2006 Jan;73(1):79-80. doi: 10.1007/BF02758266.
The treatment of children with short stature was revolutionized by the creation of recombinant growth hormone therapy. While it cannot be denied that therapy adds significant height to children who are growth hormone deficient, such treatment is both painful, requiring many injections for years, as well as extremely expensive, both for the children's parents as well as for medical health care for society. With the indications for growth hormone treatment expanding over the years to include children with short stature who are not growth hormone deficient, it is important to determine all potential benefits beyond the obvious physical effects in order to make efficient cost-benefit determinations on appropriate usage of growth hormone therapy. One aspect of possible benefits for these children with short stature may be psychological features, such as increased overall happiness and self-esteem that is gained with increased height. A review and analysis of literature was undertaken in order to determine what effect, if any, growth hormone therapy has on short children's psychosocial well-being.
重组生长激素疗法的出现彻底改变了对身材矮小儿童的治疗方式。不可否认的是，这种疗法能让生长激素缺乏的儿童显著长高，但这种治疗既痛苦，需要多年多次注射，又极其昂贵，对孩子的父母以及社会医疗保健系统来说都是如此。随着多年来生长激素治疗的适应症不断扩大，将身材矮小但并非生长激素缺乏的儿童也纳入其中，为了对生长激素疗法的合理使用做出有效的成本效益评估，确定除了明显的身体影响之外的所有潜在益处就变得很重要。对于这些身材矮小的儿童来说，可能的益处之一或许是心理方面的，比如随着身高增加而获得的整体幸福感和自尊感的提升。为了确定生长激素疗法对身材矮小儿童的心理社会幸福感是否有影响（若有影响则具体是什么影响），我们对相关文献进行了综述和分析。
