Parnavelas J G
Department of Anatomy and Developmental Biology, University College London, London, UK.
Braz J Med Biol Res. 2002 Dec;35(12):1423-9. doi: 10.1590/s0100-879x2002001200003.
Neurons of the mammalian cerebral cortex comprise two broad classes: pyramidal neurons, which project to distant targets, and the inhibitory nonpyramidal cells, the cortical interneurons. Pyramidal neurons are generated in the germinal ventricular zone, which lines the lateral ventricles, and migrate along the processes of radial glial cells to their positions in the developing cortex in an 'inside-out' sequence. The GABA-containing nonpyramidal cells originate for the most part in the ganglionic eminence, the primordium of the basal ganglia in the ventral telencephalon. These cells follow tangential migratory routes to enter the cortex and are in close association with the corticofugal axonal system. Once they enter the cortex, they move towards the ventricular zone, possibly to obtain positional information, before they migrate radially in the direction of the pial surface to take up their positions in the developing cortex. The mechanisms that guide interneurons throughout these long and complex migratory routes are currently under investigation.
投射到远处目标的锥体神经元，以及抑制性的非锥体细胞，即皮层中间神经元。锥体神经元在衬于侧脑室的生发脑室区产生，并沿着放射状胶质细胞的突起，以“由内向外”的顺序迁移到发育中的皮层中的位置。含γ-氨基丁酸的非锥体细胞大多起源于神经节隆起，即腹侧端脑中基底神经节的原基。这些细胞沿着切线迁移路径进入皮层，并与皮质离心轴突系统密切相关。一旦它们进入皮层，就会向脑室区移动，可能是为了获取位置信息，然后再沿软脑膜表面的方向径向迁移，以在发育中的皮层中占据其位置。目前正在研究引导中间神经元完成这些漫长而复杂迁移路径的机制。
