Collins-Schramm Heather E, Kittles Rick A, Operario Darwin J, Weber James L, Criswell Lindsey A, Cooper Richard S, Seldin Michael F
Rowe Program in Human Genetics, Department of Biological Chemistry, University of California at Davis, One Shields Avenue, Davis, CA 95616-8669, USA.
Hum Genet. 2002 Dec;111(6):566-9. doi: 10.1007/s00439-002-0818-z. Epub 2002 Sep 14.
Markers informative for ancestry are necessary for admixture mapping and improving case-control association analyses. In particular, African Americans are an admixed population for which genetic studies require accurately evaluating admixture. This will require markers that can be used in African Americans to determine if a given genomic region is of European or African ancestry. This report shows that, despite studies indicating high intra-African sequence variation, markers with large inter-ethnic differences have only small variations in allele distribution among divergent African populations and should be valuable for evaluating admixture in complex disease genetic studies.
用于血统分析的标记物对于混合映射和改进病例对照关联分析是必要的。特别是，非裔美国人是一个混合群体，其基因研究需要准确评估混合情况。这将需要能够用于非裔美国人的标记物，以确定给定的基因组区域是欧洲血统还是非洲血统。本报告表明，尽管有研究表明非洲内部存在高度的序列变异，但具有较大种族间差异的标记物在不同非洲人群中的等位基因分布只有很小的差异，并且在复杂疾病基因研究中评估混合情况时应该很有价值。
