Grunow W, Altmann H J, Böhme C
Arch Toxicol. 1975 Dec 18;34(4):315-24. doi: 10.1007/BF00353851.
3-Amino-1,2,4-triazole[5-(14)C] was administered orally to rats as a single dose of 50 mg/kg body weight. Excretion in urine and feces was followed during a period of 3 days. Within the first 24 hrs the main part of the radioactivity was found in the urine as unchanged amitrole. 3-Amino-5-mercapto-1,2,4-triazole and 3-amino-1,2,4-triazolyl-(5)-mercapturic acid were isolated from urine and identified by comparison with synthetic compounds. The total amount of these metabolites in the urine was about 6% of the dose. The metabolic pathways of amitrole and the possible relations between biotransformation and toxicity are discussed.
将3-氨基-1,2,4-三唑[5-(14)C]以50毫克/千克体重的单剂量口服给予大鼠。在3天的时间内追踪其在尿液和粪便中的排泄情况。在最初的24小时内，放射性的主要部分在尿液中以未变化的杀草强形式存在。从尿液中分离出3-氨基-5-巯基-1,2,4-三唑和3-氨基-1,2,4-三唑基-(5)-巯基尿酸，并通过与合成化合物比较进行鉴定。这些代谢物在尿液中的总量约为剂量的6%。讨论了杀草强的代谢途径以及生物转化与毒性之间的可能关系。
