Aviv Abraham
Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA.
J Mol Med (Berl). 2002 Nov;80(11):689-95. doi: 10.1007/s00109-002-0377-8. Epub 2002 Sep 13.
By undergoing erosion with each replicative cycle, telomeres chronicle the replicative history of human somatic cells in vitro and in vivo. In human beings the telomere is relatively short, inversely correlated with age, highly heritable, and longer in women than men. However, it is not established whether the dynamics of telomere attrition in vivo has a role in the biology of human aging. Telomere attrition may be modified by reactive oxygen species, the biology of which is governed by processes that are influenced by sex. Indices of cardiovascular aging in humans are correlated with telomere length and this relationship is characterized by sexual dimorphism. In the final analysis, the biology of reactive oxygen species may offer a common explanation for some interindividual variation in cardiovascular aging and age-dependent telomere attrition in humans.
在每个复制周期中，端粒都会受到侵蚀，从而记录了人类体细胞在体外和体内的复制历史。在人类中，端粒相对较短，与年龄呈负相关，具有高度遗传性，且女性的端粒比男性长。然而，体内端粒损耗的动态变化是否在人类衰老生物学中起作用尚未确定。活性氧可能会改变端粒损耗，而活性氧的生物学特性受性别影响的过程所支配。人类心血管衰老指标与端粒长度相关，这种关系具有性别二态性。归根结底，活性氧的生物学特性可能为人类心血管衰老和年龄依赖性端粒损耗的个体间差异提供一个共同的解释。
