Guerrero-Peral A B, Guerrero-Peral A L, Carrascal Y, Bustamante R, Rodríguez M A, Ponce-Villares M A, Bueno-Rodríguez V
Servicio de Análisis Clínicos. Hospital Universitario de Valladolid. Valladolid, España.
Rev Neurol. 2002;35(10):901-4.
It is thought that any acute damage to the central nervous system and, more particularly, acute cerebrovascular disease (ACVD) can give rise to a myocardial lesion. Our aim is to apply the latest biochemical markers (troponin T, troponin I and myoglobin) to the study of this problem.
We conducted a retrospective study of 42 patients who were consecutively admitted to hospital with ACVD. The pathological antecedents and the clinical and electrocardiographic variables were considered in each case. A single determination of CK, CK MB, myoglobin, troponin T and troponin I was performed for each patient.
The determination of the new biochemical markers was positive in a higher number of cases than CK and its MB fraction, or electrocardiographic alterations. This positivity, together with the troponin T and troponin I values correlate with mortality.
We present the first research work to be published in Spanish that studies the new biochemical markers of myocardial damage in ACVD. We urge researchers to carry out further analyses on more extensive series in order to determine the influence myocardial damage has on mortality and to establish suitable therapeutic measures. This will also allow us to find out whether a certain location or size of the lesion can give rise to a higher predisposition to this kind of damage
人们认为，中枢神经系统的任何急性损伤，尤其是急性脑血管疾病（ACVD），都可能引发心肌损伤。我们的目的是应用最新的生化标志物（肌钙蛋白T、肌钙蛋白I和肌红蛋白）来研究这一问题。
我们对42例因ACVD连续入院的患者进行了回顾性研究。每种情况下都考虑了病理病史以及临床和心电图变量。对每位患者进行了一次肌酸激酶（CK）、肌酸激酶同工酶（CK MB）、肌红蛋白、肌钙蛋白T和肌钙蛋白I的测定。
新生化标志物测定呈阳性的病例数多于CK及其同工酶部分，或心电图改变。这种阳性结果，连同肌钙蛋白T和肌钙蛋白I的值与死亡率相关。
我们展示了第一篇以西班牙语发表的研究ACVD中心肌损伤新生化标志物的研究工作。我们敦促研究人员对更广泛的系列进行进一步分析，以确定心肌损伤对死亡率的影响，并建立合适的治疗措施。这也将使我们能够查明病变的特定位置或大小是否会导致对这种损伤的更高易感性。
