Lee Joyce M, Sundel Robert P, Liang Marilyn G
Department of Medicine, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Pediatr Dermatol. 2002 Nov-Dec;19(6):532-5. doi: 10.1046/j.1525-1470.2002.00227.x.
A previously healthy 7-year-old boy presented with polyarthritis and skin lesions. Multiple, skin- to pink-colored, firm papules were noted on the periungual areas, hands, feet, and nose. There was swelling of the proximal interphalangeal joints, wrists, elbows, ankles, and knees. A skin biopsy specimen revealed dermal fibrosis and interspersed histiocytes and lymphocytes. These findings were consistent with fibroblastic rheumatism, a condition characterized by cutaneous nodules and a symmetric polyarthritis. He was treated with methotrexate and corticosteroids with improvement in the symptoms of his arthritis and skin lesions. This early treatment was beneficial in our patient.
一名既往健康的7岁男孩出现多关节炎和皮肤病变。在甲周区域、手、脚和鼻子上发现多个粉红色、质地坚硬的丘疹。近端指间关节、腕关节、肘关节、踝关节和膝关节有肿胀。皮肤活检标本显示真皮纤维化，并有散在的组织细胞和淋巴细胞。这些发现符合纤维母细胞性风湿病，这是一种以皮肤结节和对称性多关节炎为特征的疾病。他接受了甲氨蝶呤和皮质类固醇治疗，关节炎和皮肤病变症状有所改善。这种早期治疗对我们的患者有益。
