Fam A G, Hanna W, Mak V, Assaad D
Division of Rheumatology, Sunnybrook Health Science Centre, Toronto, Ontario, Canada.
J Rheumatol. 1998 Nov;25(11):2261-6.
Correlation of the clinical manifestations of a patient with fibroblastic rheumatism with sequential skin biopsy findings revealed an early inflammatory stage with cutaneous nodules, patchy erythematous skin lesions, polyarthritis, dermal lymphomonocytic infiltrates, and fibroblastic and myofibroblastic proliferation, followed by a chronic stage with sclerodactyly, joint ankylosis, deformities and dense dermal fibrosis. Treatment of this rare disorder in its early active stages may prevent the development of incapacitating joint sequelae.
对一名纤维母细胞性风湿病患者的临床表现与连续皮肤活检结果的相关性研究显示，早期炎症阶段表现为皮肤结节、斑片状红斑性皮肤病变、多关节炎、真皮层淋巴细胞浸润以及纤维母细胞和肌纤维母细胞增殖，随后进入慢性阶段，出现指（趾）硬化、关节强直、畸形和致密的真皮纤维化。在这种罕见疾病的早期活动阶段进行治疗，可能会预防导致关节功能丧失的后遗症的发生。
