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Infect Immun. 2002 Dec;70(12):7176-8. doi: 10.1128/IAI.70.12.7176-7178.2002.
2
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本文引用的文献

1
The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae.pgdA基因编码肺炎链球菌中的一种肽聚糖N - 乙酰葡糖胺脱乙酰酶。
J Biol Chem. 2000 Jul 7;275(27):20496-501. doi: 10.1074/jbc.M910189199.
2
Analysis of peptidoglycan structure from vegetative cells of Bacillus subtilis 168 and role of PBP 5 in peptidoglycan maturation.枯草芽孢杆菌168营养细胞肽聚糖结构分析及PBP 5在肽聚糖成熟中的作用
J Bacteriol. 1999 Jul;181(13):3956-66. doi: 10.1128/JB.181.13.3956-3966.1999.
3
Possible role of a choline-containing teichoic acid in the maintenance of normal cell shape and physiology in Streptococcus oralis.含胆碱磷壁酸在口腔链球菌维持正常细胞形态和生理功能中的可能作用。
J Bacteriol. 1993 Mar;175(6):1717-22. doi: 10.1128/jb.175.6.1717-1722.1993.
4
Triggering of pneumococcal autolysis by lysozyme.溶菌酶引发肺炎球菌自溶
J Infect Dis. 1993 Mar;167(3):684-90. doi: 10.1093/infdis/167.3.684.
5
Enzymatic deacetylation of N-acetylglucosamine residues in peptidoglycan from Bacillus cereus cell walls.蜡样芽孢杆菌细胞壁肽聚糖中N-乙酰葡糖胺残基的酶促脱乙酰作用。
Biochem Biophys Res Commun. 1971 Nov 5;45(3):751-8. doi: 10.1016/0006-291x(71)90481-5.
6
Cerebrospinal fluid lysozyme in bacterial and viral meningitis.细菌性和病毒性脑膜炎中的脑脊液溶菌酶
Acta Med Scand. 1978;203(1-2):71-4. doi: 10.1111/j.0954-6820.1978.tb14834.x.
7
The action of lysozyme on peptidoglycan with N-unsubstituted glucosamine residues. Isolation of glycan fragments and their susceptibility to lysozyme.溶菌酶对含有N-未取代葡糖胺残基的肽聚糖的作用。聚糖片段的分离及其对溶菌酶的敏感性。
Eur J Biochem. 1977 Jun 1;76(1):299-307. doi: 10.1111/j.1432-1033.1977.tb11596.x.
8
Effects of lysozyme on Bacillus cereus 569: rupture of chains of bacteria and enhancement of sensitivity to autolysins.溶菌酶对蜡样芽孢杆菌569的影响：细菌链的断裂及对自溶素敏感性的增强。
J Gen Microbiol. 1979 Nov;115(1):1-11. doi: 10.1099/00221287-115-1-1.

肽聚糖N - 乙酰葡糖胺脱乙酰酶，一种肺炎链球菌中假定的毒力因子。

Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae.

作者信息

Vollmer Waldemar, Tomasz Alexander

机构信息

Laboratory of Microbiology, The Rockefeller University, New York, New York 10021, USA.

出版信息

Infect Immun. 2002 Dec;70(12):7176-8. doi: 10.1128/IAI.70.12.7176-7178.2002.

DOI:10.1128/IAI.70.12.7176-7178.2002
PMID:12438406
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC133073/
Abstract

Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model.

摘要

肺炎球菌肽聚糖（PG）的许多氨基葡萄糖残基未被乙酰化，这使得PG对溶菌酶具有抗性。一个pgdA基因（编码肽聚糖N - 乙酰葡糖胺脱乙酰酶A）失活的Ⅲ型荚膜突变体对外源溶菌酶变得高度敏感，并且在腹腔小鼠模型中显示出毒力降低。