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西尼罗河病毒包膜蛋白结构域III内中和表位的鉴定

Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein.

作者信息

Beasley David W C, Barrett Alan D T

机构信息

WHO Collaborating Center for Tropical Diseases, Sealy Center for Vaccine Development, Department of Pathology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0609, USA.

出版信息

J Virol. 2002 Dec;76(24):13097-100. doi: 10.1128/jvi.76.24.13097-13100.2002.

DOI:10.1128/jvi.76.24.13097-13100.2002
PMID:12438639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC136710/
Abstract

Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330, and E332.

摘要

利用一组中和性单克隆抗体，我们已绘制出西尼罗河病毒纽约株包膜蛋白结构域III中的表位。识别这些表位的单克隆抗体中和病毒的能力在I型和II型西尼罗河病毒株之间似乎有所不同，且表位位于结构域III上表面的E307、E330和E332残基处。

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Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype.西尼罗河病毒株的小鼠神经侵袭性表型因病毒基因型而异。
Virology. 2002 Apr 25;296(1):17-23. doi: 10.1006/viro.2002.1372.
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J Virol. 2001 Aug;75(16):7769-73. doi: 10.1128/JVI.75.16.7769-7773.2001.
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Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: insight into the neutralization mechanism.对所有血清型登革病毒感染性至关重要的中和表位的定位：对中和机制的深入了解
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Virology. 2001 Jul 20;286(1):54-61. doi: 10.1006/viro.2001.0959.
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