Sharpe Arlene H, Freeman Gordon J
Immunology Research Division, Department of Pathology, Brigham, and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA.
Nat Rev Immunol. 2002 Feb;2(2):116-26. doi: 10.1038/nri727.
The B7-1/B7-2-CD28/CTLA-4 pathway is crucial in regulating T-cell activation and tolerance. New B7 and CD28 molecules have recently been discovered and new pathways have been delineated that seem to be important for regulating the responses of previously activated T cells. Several B7 homologues are expressed on cells other than professional antigen-presenting cells, indicating new mechanisms for regulating T-cell responses in peripheral tissues. Some B7 homologues have unknown receptors, indicating that other immunoregulatory pathways remain to be described. Here, we summarize our current understanding of the new members of the B7 and CD28 families, and discuss their therapeutic potential.
B7-1/B7-2-CD28/CTLA-4通路在调节T细胞活化和耐受性方面至关重要。最近发现了新的B7和CD28分子，并描绘了新的通路，这些通路似乎对调节先前活化的T细胞反应很重要。几种B7同源物在专职抗原呈递细胞以外的细胞上表达，这表明在外周组织中调节T细胞反应有新机制。一些B7同源物具有未知受体，这表明其他免疫调节通路有待描述。在这里，我们总结了目前对B7和CD28家族新成员的理解，并讨论了它们的治疗潜力。
