人类T细胞激活连接蛋白（LAT）基因的染色体定位与基因组结构
Chromosomal localization and genomic organization of the human Linker for Activation of T cells (LAT) gene.
作者信息
Windpassinger C, Kroisel P M, Wagner K, Petek E
机构信息
Institute of Medical Biology and Human Genetics, University of Graz, Graz, Austria.
出版信息
Cytogenet Genome Res. 2002;97(3-4):155-7. doi: 10.1159/000066598.
We have mapped the LAT gene by radiation hybrid mapping and fluorescence in situ hybridization to chromosome 16p11.2. The complete cDNA sequence of LAT was generated using assembled sequences of cDNA fragments already available. BLAST analysis using the cDNA sequence led to the identification of BAC clone CTB-134H23 (GenBank Accession No. AC112166). The genomic structure of the human LAT gene consists of 11 exons, encompassing 5.7 kb. Alternative splicing variants were identified.
我们通过辐射杂交图谱和荧光原位杂交技术将LAT基因定位于染色体16p11.2。利用已有的cDNA片段组装序列生成了LAT的完整cDNA序列。使用该cDNA序列进行BLAST分析，鉴定出BAC克隆CTB - 134H23（GenBank登录号AC112166）。人类LAT基因的基因组结构由11个外显子组成，全长5.7 kb。还鉴定出了可变剪接变体。
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