小鼠基因组中三个液泡H⁺ -ATP酶16 kDa亚基（ATP6V0C）基因的染色体定位

Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genome.

作者信息

Simckes A M, Swanson S K, White R A

机构信息

Division of Pediatric Nephrology, The Children's Mercy Hospital, UMKC School of Medicine, Kansas City, MO 64108, USA.

出版信息

Cytogenet Genome Res. 2002;97(1-2):111-5. doi: 10.1159/000064065.

DOI:10.1159/000064065

PMID:12438748

Abstract

Vacuolar-H(+)-ATPase (V-H-ATPase) is a large multimeric protein composed of at least 12 distinct subunits. The 16-kDa hydrophobic proteolipid subunit (ATP6V0C; ATPase, H(+ )transporting, lysosomal 16 kDa, V0 subunit C) plays a central role in H(+) transport across cellular membranes. We have mapped three ATP6V0C genes (Atp6v0c, Atp6v0c-ps1 and Atp6voc-ps2) in the murine genome. Atp6v0c-ps1 and Atp6v0c-ps2 map to Chromosomes 7 and 6, respectively. Atp6v0c maps to Chromosome 17, closely linked to the Tsc2 locus and D17Mit55. This region of Chromosome 17 in mouse is homologous with chromosome 16 in human where the ATP6V0C gene is localized.

摘要

液泡型H(+)-ATP酶（V-H-ATP酶）是一种由至少12个不同亚基组成的大型多聚体蛋白。16 kDa疏水蛋白脂质亚基（ATP6V0C；ATP酶，H(+)转运，溶酶体16 kDa，V0亚基C）在H(+)跨细胞膜转运中起核心作用。我们已在小鼠基因组中定位了三个ATP6V0C基因（Atp6v0c、Atp6v0c-ps1和Atp6voc-ps2）。Atp6v0c-ps1和Atp6v0c-ps2分别定位于第7号和第6号染色体。Atp6v0c定位于第17号染色体，与Tsc2基因座和D17Mit55紧密连锁。小鼠第17号染色体的这个区域与人类第16号染色体同源，ATP6V0C基因定位于此。