苯妥英的生物利用度。两种制剂的比较。
Bioavailability of phenytoin. A comparison of two preparations.
作者信息
Stewart M J, Ballinger B R, Devlin E J, Miller A Y, Ramsay A C
出版信息
Eur J Clin Pharmacol. 1975 Dec 19;9(2-3):209-12. doi: 10.1007/BF00614019.
PMID:1243984
Abstract
Plasma phenytoin levels were measured in 60 patients under steady-state conditions for a period of six weeks. During the trial, the preparation of phenytoin was changed from Phenytoin BP (Regent) to Epanutin Infatabs. A significant increase in plasma phenytoin levels following the change of tablet was matched by a decrease in the number of seizures.
摘要
在60名患者处于稳态条件下的六周时间内测量了血浆苯妥英水平。在试验期间，苯妥英的制剂从苯妥英英国药典（Regent）换成了苯妥英长效片。片剂更换后血浆苯妥英水平显著升高，同时癫痫发作次数减少。
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