Terada Kihei, Niizuma Takahiro
Department of Pediatrics, Kawasaki Medical School.
Nihon Rinsho. 2002 Nov;60(11):2225-9.
We reviewed vaccine development in the past, at present and possible future, and described new vaccines, which will be introduced in Japan in the near future. The introduction of gene technology has promoted advances in vaccines. A subunit vaccine of hepatitis B, a recombinant vaccine for rotavirus and an enhanced inactivated polio vaccine have been developed. DNA vaccines and mucosal vaccines with adjuvants have been studied recently. They are promising, but safety, cost and benefits should be taken into consideration for vaccine development. In Japan, we cannot use MMR vaccines, but MR or imported MMR vaccines have been tested and are awaiting approval. Hemophilus influenzae type b vaccine and inactivated polio vaccine are also awaiting approval in Japan.
我们回顾了过去、现在及未来可能的疫苗研发情况，并介绍了不久后将在日本推出的新型疫苗。基因技术的引入推动了疫苗的发展。已经研发出了乙型肝炎亚单位疫苗、轮状病毒重组疫苗以及强化灭活脊髓灰质炎疫苗。近期还对DNA疫苗和含佐剂的黏膜疫苗进行了研究。它们前景广阔，但在疫苗研发中应考虑安全性、成本和效益。在日本，我们不能使用麻疹、腮腺炎和风疹联合疫苗（MMR疫苗），但麻疹和风疹联合疫苗（MR疫苗）或进口的MMR疫苗已通过测试，正在等待获批。b型流感嗜血杆菌疫苗和灭活脊髓灰质炎疫苗在日本也正在等待获批。
