Tomsig J L, Creutz C E
Department of Pharmacology, University of Virginia, Charlottesville 22908, USA.
Cell Mol Life Sci. 2002 Sep;59(9):1467-77. doi: 10.1007/s00018-002-8522-7.
The copines are a novel family of ubiquitous Ca(2+)-dependent, phospholipid-binding proteins. They contain two Ca(2+)- and phospholipid-binding domains known as 'C2 domains' present in proteins such as protein kinase C, phospholipase C and synaptotagmin. Copines are thought to be involved in membrane-trafficking phenomena because of their phospholipid-binding properties. They may also be involved in protein-protein interactions since they contain a domain similar to the protein-binding 'A domain' of integrins. The biochemistry, gene structure, tissue distribution and possible biological roles of copines are discussed, including recent observations with Arabidopsis that indicate that copines may be involved in cell division and growth.
柯平蛋白是一类新的普遍存在的依赖钙离子的磷脂结合蛋白家族。它们含有两个钙离子和磷脂结合结构域，即“C2结构域”，存在于蛋白激酶C、磷脂酶C和突触结合蛋白等蛋白质中。由于其磷脂结合特性，柯平蛋白被认为参与膜运输现象。它们也可能参与蛋白质-蛋白质相互作用，因为它们含有一个与整合素的蛋白质结合“A结构域”相似的结构域。本文讨论了柯平蛋白的生物化学、基因结构、组织分布和可能的生物学作用，包括最近对拟南芥的观察结果，这些结果表明柯平蛋白可能参与细胞分裂和生长。
