通过铑催化的C-H键活化实现可异构化烯烃与杂环的分子间偶联。
Intermolecular coupling of isomerizable alkenes to heterocycles via rhodium-catalyzed C-H bond activation.
作者信息
Tan Kian L, Bergman Robert G, Ellman Jonathan A
机构信息
Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720, USA.
出版信息
J Am Chem Soc. 2002 Nov 27;124(47):13964-5. doi: 10.1021/ja0281129.
PMID:12440873
Abstract
This reports first intermolecular coupling of unactivated alkenes, including isomerizable alkenes, to a range of heterocycles using a Rh(I) catalyst. A variety of functional groups were incorporated, including esters, nitriles, and acetals. The intermolecular coupling became possible after it was discovered that weak acids dramatically increase the rate of both the inter- and intramolecular reactions.
摘要
本报告首次使用铑（I）催化剂将未活化的烯烃（包括可异构化烯烃）与一系列杂环进行分子间偶联。引入了多种官能团，包括酯、腈和缩醛。在发现弱酸能显著提高分子间和分子内反应速率后，分子间偶联成为可能。
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