Roughley P J, Alini M, Antoniou J
Genetics Unit, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, Quebec, H3G 1A6, Canada.
Biochem Soc Trans. 2002 Nov;30(Pt 6):869-74. doi: 10.1042/bst0300869.
The ability of the nucleus pulposus of the intervertebral disc to resist compressive loads is due to its high content of the proteoglycan aggrecan. Degeneration of the intervertebral disc is preceded and accompanied by a loss of aggrecan due to proteolysis. Biological repair of intervertebral disc degeneration should strive to restore aggrecan content to its optimal functional level. One approach to such repair is to supplement the degenerate nucleus with cells that are capable of aggrecan synthesis. Such cells can be supported in a biomolecular scaffold, but it is essential that the scaffold is compatible with high aggrecan retention if a functional tissue is to be attained.
椎间盘髓核抵抗压缩负荷的能力归因于其蛋白聚糖聚集蛋白聚糖的高含量。椎间盘退变之前及过程中，由于蛋白水解，聚集蛋白聚糖会流失。椎间盘退变的生物修复应努力将聚集蛋白聚糖含量恢复到其最佳功能水平。这种修复的一种方法是向退变的髓核中补充能够合成聚集蛋白聚糖的细胞。此类细胞可在生物分子支架中得到支持，但如果要获得功能性组织，支架必须与高聚集蛋白聚糖保留率兼容。
