Horton J D
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75390-9046, USA.
Biochem Soc Trans. 2002 Nov;30(Pt 6):1091-5. doi: 10.1042/bst0301091.
Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP isoforms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids. The unique regulation and activation properties of each SREBP isoform facilitates the co-ordinate regulation of all essential lipid building blocks required for cell membranes as well as for very-low-density lipoprotein formation in hepatocytes.
固醇调节元件结合蛋白（SREBPs）是一类调节脂质稳态的转录因子家族。三种SREBP亚型控制着胆固醇、脂肪酸、三酰甘油和磷脂生物合成所需的30多个基因的表达。每种SREBP亚型独特的调节和激活特性有助于协调调节细胞膜以及肝细胞中极低密度脂蛋白形成所需的所有必需脂质成分。
