Laboratory of Immunopharmacology, Department of Physiology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
Neuroscience Graduate Program, Federal Fluminense University, Niteroi, Brazil.
Front Immunol. 2023 Aug 3;14:1224335. doi: 10.3389/fimmu.2023.1224335. eCollection 2023.
Sepsis is a life-threatening organ dysfunction caused by abnormal host response to infection. Millions of people are affected annually worldwide. Derangement of the inflammatory response is crucial in sepsis pathogenesis. However, metabolic, coagulation, and thermoregulatory alterations also occur in patients with sepsis. Fatty acid mobilization and oxidation changes may assume the role of a protagonist in sepsis pathogenesis. Lipid oxidation and free fatty acids (FFAs) are potentially valuable markers for sepsis diagnosis and prognosis. Herein, we discuss inflammatory and metabolic dysfunction during sepsis, focusing on fatty acid oxidation (FAO) alterations in the liver and muscle (skeletal and cardiac) and their implications in sepsis development.
脓毒症是一种危及生命的器官功能障碍，由宿主对感染的异常反应引起。全球每年有数百万患者受到影响。炎症反应的紊乱在脓毒症发病机制中至关重要。然而，脓毒症患者也会发生代谢、凝血和体温调节的改变。脂肪酸动员和氧化的改变可能在脓毒症发病机制中起关键作用。脂质氧化和游离脂肪酸（FFAs）可能是脓毒症诊断和预后的有价值标志物。在此，我们讨论脓毒症期间的炎症和代谢功能障碍，重点讨论肝脏和肌肉（骨骼肌和心肌）中脂肪酸氧化（FAO）的改变及其对脓毒症发展的影响。
