Thimme Robert, Bukh Jens, Spangenberg Hans Christian, Wieland Stefan, Pemberton Janell, Steiger Carola, Govindarajan Sugantha, Purcell Robert H, Chisari Francis V
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15661-8. doi: 10.1073/pnas.202608299. Epub 2002 Nov 19.
To define the early events that determine the outcome of acute hepatitis C virus (HCV) infection, we compared the course of viremia with the peripheral and intrahepatic T cell response and intrahepatic cytokine profile in six acutely infected chimpanzees. Three different outcomes were observed after peak viral titers were reached: sustained viral clearance, transient viral clearance followed by chronic infection, and chronic infection that persisted at initial peak titers. The results indicate that HCV spread outpaces the T cell response and that HCV rapidly induces but is not controlled by IFN-alphabeta; that viral clearance follows the entry and accumulation of HCV-specific IFN-gamma-producing T cells in the liver; and that it may not require the destruction of infected cells.
为了确定决定急性丙型肝炎病毒（HCV）感染结果的早期事件，我们比较了6只急性感染黑猩猩的病毒血症过程、外周血和肝内T细胞反应以及肝内细胞因子谱。在达到病毒滴度峰值后观察到三种不同的结果：病毒持续清除、短暂病毒清除后转为慢性感染以及慢性感染持续在初始峰值滴度水平。结果表明，HCV的传播速度超过T细胞反应，HCV能迅速诱导但不受IFN-αβ控制；病毒清除伴随着HCV特异性产生IFN-γ的T细胞在肝脏中的进入和积累；并且可能不需要破坏被感染的细胞。
