Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions.

作者信息

Schweighardt Becky, Ortiz Gabriel M, Grant Robert M, Wellons Melissa, Miralles G Diego, Kostrikis Leondios G, Bartlett John A, Nixon Douglas F

机构信息

Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, USA.

出版信息

AIDS. 2002 Nov 22;16(17):2342-4. doi: 10.1097/00002030-200211220-00018.

We report the emergence of drug-resistant viral mutations in chronically HIV-infected individual undergoing structured treatment interruptions (STI). THe protease mutations K101E and K103N were detected at the end of the second or third STI. We concluded that the repeated abrupt termination and resumption of certain antiretroviral drug regimens during STI therapy may lead to the development of drug resistance in chronically HIV-infected individuals.