2'-脱氧腺苷与硝酸铜（II）/乙酸酐反应生成2'-脱氧-2-硝基腺苷。

Formation of 2'-deoxy-2-nitroadenosines by reaction of 2'-deoxyadenosines with copper(II) nitrate/acetic anhydride.

作者信息

Kaiya Toyo, Tanaka Haruko, Kohda Kohfuku

机构信息

Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2002 Jun-Jul;21(6-7):427-33. doi: 10.1081/NCN-120014815.

DOI:10.1081/NCN-120014815

PMID:12442960

Abstract

Nitration of 9-substituted [ethyl, (Ac)2-2'-deoxyribosyl, (Ac)3-ribosyl] N6-acetyladenine derivatives with Cu(NO3)2.3H2O/Ac2O was examined. Nitration proceeded at the 2-position, although the yield was low. Removal of the acetyl groups gave 2'-deoxy-2-nitroadenosine derivatives.

摘要

研究了用Cu(NO₃)₂·3H₂O/Ac₂O对9-取代的[N⁶-乙酰腺嘌呤衍生物（乙基、(Ac)₂-2'-脱氧核糖基、(Ac)₃-核糖基）]进行硝化反应。硝化反应在2-位进行，尽管产率较低。脱去乙酰基得到2'-脱氧-2-硝基腺苷衍生物。